Original works and inventions since ancient times recognized for their value, today are well protected by law. Intellectual property (IP) so far “down to Earth”, as works and inventions are created on Earth. Since IP legally requires originality and new solution for a technical problem, space activities provide plenty of opportunities to legal protection of IP, to stimulate and attract creativity and investments. Therefore, Space represents an opportunity and a challenge for IP, especially complex in international cooperation schemes, which create situations of parallel applications in several jurisdictions: telecommunication services, EO big data mixing, exploration missions such as ISS Intergovernmental Agreement, sample returns.